Cells of transitional epithelium are large and plump when the bladder is empty. When the bladder is full, they become flattened. Occasionally, a binucleate cell (black arrow) can be seen. Notice the infiltrate of lymphocytes (blue arrows) and an increased density of staining along the apical surface of the most superficial layer of epithelial cells. Is there a specialization of the plasma membrane at this surface exposed to the urine?
Bar = 50 Microns
